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Dopaminergic neurons modulate GABA neuron migration in the embryonic midbrain.

ABSTRACT: Neuronal migration, a key event during brain development, remains largely unexplored in the mesencephalon, where dopaminergic (DA) and GABA neurons constitute two major neuronal populations. Here we study the migrational trajectories of DA and GABA neurons and show that they occupy ventral mesencephalic territory in a temporally and spatially specific manner. Our results from the Pitx3-deficient aphakia mouse suggest that pre-existing DA neurons modulate GABA neuronal migration to their final destination, providing novel insights and fresh perspectives concerning neuronal migration and connectivity in the mesencephalon in normal as well as diseased brains.

SUBMITTER: Vasudevan A 

PROVIDER: S-EPMC3413160 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature

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Dopaminergic neurons modulate GABA neuron migration in the embryonic midbrain.

Vasudevan Anju A   Won Chungkil C   Li Suyan S   Erdélyi Ferenc F   Szabó Gábor G   Kim Kwang-Soo KS  

Development (Cambridge, England) 20120901 17

Neuronal migration, a key event during brain development, remains largely unexplored in the mesencephalon, where dopaminergic (DA) and GABA neurons constitute two major neuronal populations. Here we study the migrational trajectories of DA and GABA neurons and show that they occupy ventral mesencephalic territory in a temporally and spatially specific manner. Our results from the Pitx3-deficient aphakia mouse suggest that pre-existing DA neurons modulate GABA neuronal migration to their final de  ...[more]