Ontology highlight
ABSTRACT:
SUBMITTER: Sneck M
PROVIDER: S-EPMC3413224 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Sneck Mia M Nguyen Su Duy SD Pihlajamaa Tero T Yohannes Gebrenegus G Riekkola Marja-Liisa ML Milne Ross R Kovanen Petri T PT Oörni Katariina K
Journal of lipid research 20120620 9
During atherogenesis, the extracellular pH of atherosclerotic lesions decreases. Here, we examined the effect of low, but physiologically plausible pH on aggregation of modified LDL, one of the key processes in atherogenesis. LDL was treated with SMase, and aggregation of the SMase-treated LDL was followed at pH 5.5-7.5. The lower the pH, the more extensive was the aggregation of identically prelipolyzed LDL particles. At pH 5.5-6.0, the aggregates were much larger (size >1 µm) than those formed ...[more]