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Targeted and armed oncolytic adenovirus via chemoselective modification.


ABSTRACT: Oncolytic adenoviruses (Ads) are an emerging alternative therapy for cancer; however, clinical trial have not yet demonstrated sufficient efficacy. When oncolytic Ads are used in combination with taxoids a synergistic increase in both cytotoxicity and viral replication is observed. In order to generate a next generation oncolytic adenovirus, virion were physically conjugated to a highly potent taxoid, SB-T-1214, and a folate targeting motif. Conjugation was enabled via the metabolic incorporation of non-canonical monosaccharides (O-GlcNAz) and amino acids (homopropargylglycine), which served as sites for chemoselective modification.

SUBMITTER: Banerjee PS 

PROVIDER: S-EPMC3413283 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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Targeted and armed oncolytic adenovirus via chemoselective modification.

Banerjee Partha S PS   Zuniga Edison S ES   Ojima Iwao I   Carrico Isaac S IS  

Bioorganic & medicinal chemistry letters 20110520 17


Oncolytic adenoviruses (Ads) are an emerging alternative therapy for cancer; however, clinical trial have not yet demonstrated sufficient efficacy. When oncolytic Ads are used in combination with taxoids a synergistic increase in both cytotoxicity and viral replication is observed. In order to generate a next generation oncolytic adenovirus, virion were physically conjugated to a highly potent taxoid, SB-T-1214, and a folate targeting motif. Conjugation was enabled via the metabolic incorporatio  ...[more]

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