Targeted and armed oncolytic adenovirus via chemoselective modification.
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ABSTRACT:
SUBMITTER: Banerjee PS
PROVIDER: S-EPMC3413283 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Publications
Targeted and armed oncolytic adenovirus via chemoselective modification.
Banerjee Partha S PS Zuniga Edison S ES Ojima Iwao I Carrico Isaac S IS
Bioorganic & medicinal chemistry letters 20110520 17
Oncolytic adenoviruses (Ads) are an emerging alternative therapy for cancer; however, clinical trial have not yet demonstrated sufficient efficacy. When oncolytic Ads are used in combination with taxoids a synergistic increase in both cytotoxicity and viral replication is observed. In order to generate a next generation oncolytic adenovirus, virion were physically conjugated to a highly potent taxoid, SB-T-1214, and a folate targeting motif. Conjugation was enabled via the metabolic incorporatio ...[more]
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