Radiation-induced reprogramming of breast cancer cells.
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ABSTRACT:
SUBMITTER: Lagadec C
PROVIDER: S-EPMC3413333 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Publications
Radiation-induced reprogramming of breast cancer cells.
Lagadec Chann C Vlashi Erina E Della Donna Lorenza L Dekmezian Carmen C Pajonk Frank F
Stem cells (Dayton, Ohio) 20120501 5
Breast cancers are thought to be organized hierarchically with a small number of breast cancer stem cells (BCSCs) able to regrow a tumor while their progeny lack this ability. Recently, several groups reported enrichment for BCSCs when breast cancers were subjected to classic anticancer treatment. However, the underlying mechanisms leading to this enrichment are incompletely understood. Using non-BCSCs sorted from patient samples, we found that ionizing radiation reprogrammed differentiated brea ...[more]
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