Ontology highlight
ABSTRACT:
SUBMITTER: Chambers JE
PROVIDER: S-EPMC3413365 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Chambers Joseph E JE Petrova Kseniya K Tomba Giulia G Vendruscolo Michele M Ron David D
The Journal of cell biology 20120801 3
Gene expression programs that regulate the abundance of the chaperone BiP adapt the endoplasmic reticulum (ER) to unfolded protein load. However, such programs are slow compared with physiological fluctuations in secreted protein synthesis. While searching for mechanisms that fill this temporal gap in coping with ER stress, we found elevated levels of adenosine diphosphate (ADP)-ribosylated BiP in the inactive pancreas of fasted mice and a rapid decline in this modification in the active fed sta ...[more]