Spatial structure and Lamarckian adaptation explain extreme genetic diversity at CRISPR locus.
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ABSTRACT:
SUBMITTER: Haerter JO
PROVIDER: S-EPMC3413401 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Spatial structure and Lamarckian adaptation explain extreme genetic diversity at CRISPR locus.
Haerter Jan O JO Sneppen Kim K
mBio 20120717 4
Even within similar bacterial strains, it has been found that the clustered, regularly interspaced short palindromic repeat (CRISPR) shows a large variability of spacers. Modeling bacterial strains with different levels of immunity to infection by a single virulent phage, we find that coexistence in a well-mixed environment is possible only when these levels are distinctly different. When bacterial strains are similar, one subpopulation collapses. In the case of bacteria with various levels of C ...[more]
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2024-06-21 | GSE270448 | GEO
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