Ontology highlight
ABSTRACT:
SUBMITTER: Lara MF
PROVIDER: S-EPMC3413896 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Lara Maria Fernanda MF González-González Emilio E Speaker Tycho J TJ Hickerson Robyn P RP Leake Devin D Milstone Leonard M LM Contag Christopher H CH Kaspar Roger L RL
Human gene therapy 20120605 8
Treatment of skin disorders with short interfering RNA (siRNA)-based therapeutics requires the development of effective delivery methodologies that reach target cells in affected tissues. Successful delivery of functional siRNA to the epidermis requires (1) crossing the stratum corneum, (2) transfer across the keratinocyte membrane, followed by (3) incorporation into the RNA-induced silencing complex. We have previously demonstrated that treatment with microneedle arrays loaded with self-deliver ...[more]