Ontology highlight
ABSTRACT:
SUBMITTER: de Andrade M
PROVIDER: S-EPMC3414259 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
de Andrade Mariza M Li Yan Y Marks Randolph S RS Deschamps Claude C Scanlon Paul D PD Olswold Curtis L CL Jiang Ruoxiang R Swensen Stephen J SJ Sun Zhifu Z Cunningham Julie M JM Wampfler Jason A JA Limper Andrew H AH Midthun David E DE Yang Ping P
Cancer prevention research (Philadelphia, Pa.) 20111101 3
Chronic obstructive pulmonary disease (COPD) is a strong risk factor for lung cancer. Published studies about variations of genes encoding glutathione metabolism, DNA repair, and inflammatory response pathways in susceptibility to COPD were inconclusive. We evaluated 470 single-nucleotide polymorphisms (SNP) from 56 genes of these three pathways in 620 cases and 893 controls to identify susceptibility markers for COPD risk, using existing resources. We assessed SNP- and gene-level effects adjust ...[more]