Ontology highlight
ABSTRACT:
SUBMITTER: Zocchi L
PROVIDER: S-EPMC3414390 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Zocchi Loredana L Sassone-Corsi Paolo P
Epigenetics 20120701 7
Methyl-CpG binding protein 2 (MeCP2) binds methylated cytosines at CpG sites on DNA and it is thought to function as a critical epigenetic regulator. Mutations in the MeCP2 gene have been associated to Rett syndrome, a human neurodevelopmental disorder. Here we show that MeCP2 is acetylated by p300 and that SIRT1 mediates its deacetylation. SIRT1, the mammalian homologue of Sir2 in yeast, is a nicotinamide-adenine dinucleotide (NAD(+))-dependent histone deacetylase that belongs to the family of ...[more]