Ontology highlight
ABSTRACT:
SUBMITTER: Sebastian S
PROVIDER: S-EPMC3414820 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Sebastian Sarah S Brochet Mathieu M Collins Mark O MO Schwach Frank F Jones Matthew L ML Goulding David D Rayner Julian C JC Choudhary Jyoti S JS Billker Oliver O
Cell host & microbe 20120701 1
Calcium-dependent protein kinases (CDPKs) play key regulatory roles in the life cycle of the malaria parasite, but in many cases their precise molecular functions are unknown. Using the rodent malaria parasite Plasmodium berghei, we show that CDPK1, which is known to be essential in the asexual blood stage of the parasite, is expressed in all life stages and is indispensable during the sexual mosquito life-cycle stages. Knockdown of CDPK1 in sexual stages resulted in developmentally arrested par ...[more]