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Combination antiviral therapy for influenza: predictions from modeling of human infections.

ABSTRACT: Emergence of resistance is a major concern in influenza antiviral treatment and prophylaxis. Combination antiviral therapy might overcome this problem. Here, we estimate that all possible single mutants and a sizeable fraction of double mutants are generated during an uncomplicated influenza infection. While most of them may sustain a fitness cost, some variants may confer drug resistance and be selected during therapy. We argue that a triple combination regimen would markedly reduce the risk of antiviral resistance emergence in seasonal and pandemic influenza viruses, especially in seriously ill or immunocompromised hosts.

SUBMITTER: Perelson AS

PROVIDER: S-EPMC3415857 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature

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Combination antiviral therapy for influenza: predictions from modeling of human infections.

Perelson Alan S AS Rong Libin L Hayden Frederick G FG

The Journal of infectious diseases 20120323 11

Emergence of resistance is a major concern in influenza antiviral treatment and prophylaxis. Combination antiviral therapy might overcome this problem. Here, we estimate that all possible single mutants and a sizeable fraction of double mutants are generated during an uncomplicated influenza infection. While most of them may sustain a fitness cost, some variants may confer drug resistance and be selected during therapy. We argue that a triple combination regimen would markedly reduce the risk of ...[more]

PMID: 22448006

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