Ontology highlight
ABSTRACT:
SUBMITTER: Svensson A
PROVIDER: S-EPMC3416106 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Svensson Alexandra A Tunbäck Petra P Nordström Inger I Shestakov Andrey A Padyukov Leonid L Eriksson Kristina K
Journal of virology 20120620 17
STAT4 is an important transcription factor that contributes to the incidence and severity of different autoimmune diseases and is implicated in the antiviral immune responses in mice. In this study, we evaluated the role of STAT4 in human and murine herpes simplex virus 2 (HSV-2) infections. We show that STAT4 regulates antiviral gamma interferon (IFN-γ) responses and disease severity during chronic HSV-2 infections in humans and vaccine-induced IFN-γ-mediated protection against HSV-2 infection ...[more]