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Ovine TRIM5? can restrict visna/maedi virus.

ABSTRACT: The restrictive properties of tripartite motif-containing 5 alpha (TRIM5?) from small ruminant species have not been explored. Here, we identify highly similar TRIM5? sequences in sheep and goats. Cells transduced with ovine TRIM5? effectively restricted the lentivirus visna/maedi virus DNA synthesis. Proteasome inhibition in cells transduced with ovine TRIM5? restored restricted viral DNA synthesis, suggesting a conserved mechanism of restriction. Identification of TRIM5? active molecular species may open new prophylactic strategies against lentiviral infections.

SUBMITTER: Jauregui P

PROVIDER: S-EPMC3416128 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature

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Ovine TRIM5α can restrict visna/maedi virus.

Jáuregui P P Crespo H H Glaria I I Luján L L Contreras A A Rosati S S de Andrés D D Amorena B B Towers G J GJ Reina R R

Journal of virology 20120613 17

The restrictive properties of tripartite motif-containing 5 alpha (TRIM5α) from small ruminant species have not been explored. Here, we identify highly similar TRIM5α sequences in sheep and goats. Cells transduced with ovine TRIM5α effectively restricted the lentivirus visna/maedi virus DNA synthesis. Proteasome inhibition in cells transduced with ovine TRIM5α restored restricted viral DNA synthesis, suggesting a conserved mechanism of restriction. Identification of TRIM5α active molecular speci ...[more]

PMID: 22696640

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