Ontology highlight
ABSTRACT:
SUBMITTER: Abdel Aziz MH
PROVIDER: S-EPMC3416887 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Abdel Aziz May H MH Sidhu Preetpal Singh PS Liang Aiye A Kim Ji Yeong JY Mosier Philip D PD Zhou Qibing Q Farrell David H DH Desai Umesh R UR
Journal of medicinal chemistry 20120725 15
Earlier, we reported on the design of sulfated benzofuran dimers (SBDs) as allosteric inhibitors of thrombin (Sidhu et al. J. Med. Chem.201154 5522-5531). To identify the site of binding of SBDs, we studied thrombin inhibition in the presence of exosite 1 and 2 ligands. Whereas hirudin peptide and heparin octasaccharide did not affect the IC(50) of thrombin inhibition by a high affinity SBD, the presence of full-length heparin reduced inhibition potency by 4-fold. The presence of γ' fibrinogen p ...[more]