Ontology highlight
ABSTRACT:
SUBMITTER: Chiolo I
PROVIDER: S-EPMC3417143 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Chiolo Irene I Minoda Aki A Colmenares Serafin U SU Polyzos Aris A Costes Sylvain V SV Karpen Gary H GH
Cell 20110225 5
Double-strand breaks (DSBs) in heterochromatic repetitive DNAs pose significant threats to genome integrity, but information about how such lesions are processed and repaired is sparse. We observe dramatic expansion and dynamic protrusions of the heterochromatin domain in response to ionizing radiation (IR) in Drosophila cells. We also find that heterochromatic DSBs are repaired by homologous recombination (HR) but with striking differences from euchromatin. Proteins involved in early HR events ...[more]