Insulin activation of plasma nonesterified fatty acid uptake in metabolic syndrome.

ABSTRACT:

Objective

Insulin control of fatty acid metabolism has long been deemed dominated by suppression of adipose lipolysis. The goal of the present study was to test the hypothesis that this single role of insulin is insufficient to explain observed fatty acid dynamics.

Methods and results

Fatty acid kinetics were measured during a meal tolerance test and insulin sensitivity assessed by intravenous glucose tolerance test in overweight human subjects (n=15; body mass index, 35.8 ± 7.1 kg/m(2)). Non-steady state tracer kinetic models were formulated and tested using ProcessDB software. Suppression of adipose fatty acid release, by itself, could not account for postprandial nonesterified fatty acid concentration changes, but adipose suppression combined with insulin activation of fa

SUBMITTER: Ramos-Roman MA 

PROVIDER: S-EPMC3417322 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature