Ontology highlight
ABSTRACT:
SUBMITTER: Hildebrandt MA
PROVIDER: S-EPMC3417337 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Expert opinion on drug metabolism & toxicology 20090701 7
NSCLC is the leading cause of cancer-related death in the US. Patients with NSCLC are mostly treated with platinum-based chemotherapy, often in combination with radiation therapy. However, the development of chemo-resistance is a major hurdle limiting treatment success. In this review, we summarize the current understanding of the genetic factors modulating chemoresistance to platinum chemotherapeutics and their association with clinical outcomes for NSCLC patients. We focus on candidate pathway ...[more]