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ABSTRACT: Background
This study investigated the effects of Korean red ginseng (KRG) supplementation on metabolic parameters, inflammatory markers, and arterial stiffness in subjects with metabolic syndrome.Methods
We performed a randomized, double-blind, placebo-controlled, single-center study in 60 subjects who were not taking drugs that could affect metabolic and vascular functions. Subjects were randomized into either a KRG (4.5 g/d) group or a placebo group for a 12-week study. We collected anthropometric measurements, blood for laboratory testing, and brachial-ankle pulse wave velocity (baPWV) at the initial (week 0) and final (week 12) visits.Results
A total of 48 subjects successfully completed the study protocol. Oral administration of KRG did not significantly affect blood pressure, oxidative or inflammatory markers, or baPWV.Conclusion
We found no evidence that KRG had an effect on blood pressure, lipid profile, oxidized low density lipoprotein, fasting blood glucose, or arterial stiffness in subjects with metabolic syndrome. These findings warrant subsequent longer-term prospective clinical investigations with a larger population.Trial registration
ClinicalTrials.gov Identifier: NCT00976274.
SUBMITTER: Park BJ
PROVIDER: S-EPMC3418337 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Park Byoung-Jin BJ Lee Yong-Jae YJ Lee Hye-Ree HR Jung Dong-Hyuk DH Na Ha-Young HY Kim Hong-Bae HB Shim Jae-Yong JY
Korean journal of family medicine 20120725 4
<h4>Background</h4>This study investigated the effects of Korean red ginseng (KRG) supplementation on metabolic parameters, inflammatory markers, and arterial stiffness in subjects with metabolic syndrome.<h4>Methods</h4>We performed a randomized, double-blind, placebo-controlled, single-center study in 60 subjects who were not taking drugs that could affect metabolic and vascular functions. Subjects were randomized into either a KRG (4.5 g/d) group or a placebo group for a 12-week study. We col ...[more]