Enhancement of dorsal hippocampal activity by knockdown of HCN1 channels leads to anxiolytic- and antidepressant-like behaviors.
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ABSTRACT:
SUBMITTER: Kim CS
PROVIDER: S-EPMC3418514 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
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Enhancement of dorsal hippocampal activity by knockdown of HCN1 channels leads to anxiolytic- and antidepressant-like behaviors.
Kim Chung Sub CS Chang Payne Y PY Johnston Daniel D
Neuron 20120801 3
The hippocampus is an integral brain region for affective disorders. TRIP8b knockout mice lacking functional HCN channels as well as both HCN1 and HCN2 knockout mice have been shown to display antidepressant-like behaviors. The mechanisms or brain regions involved in these alterations in behavior, however, are not clear. We developed a lentiviral shRNA system to examine whether knockdown of HCN1 protein in the dorsal hippocampal CA1 region is sufficient to produce antidepressant-like effects. We ...[more]
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