Ontology highlight
ABSTRACT:
SUBMITTER: Schoeberl UE
PROVIDER: S-EPMC3418590 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Schoeberl Ursula E UE Kurth Henriette M HM Noto Tomoko T Mochizuki Kazufumi K
Genes & development 20120801 15
The ciliated protozoan Tetrahymena undergoes extensive programmed DNA elimination when the germline micronucleus produces the new macronucleus during sexual reproduction. DNA elimination is epigenetically controlled by DNA sequences of the parental macronuclear genome, and this epigenetic regulation is mediated by small RNAs (scan RNAs [scnRNAs]) of ∼28-30 nucleotides that are produced and function by an RNAi-related mechanism. Here, we examine scnRNA production and turnover by deep sequencing. ...[more]