Ontology highlight
ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC3419165 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Li Liangzhu L Ben Yinyin Y Zhu Zhaoqin Z Li Weihua W Xu Jianqing J Zhang Xiaoyan X
PloS one 20120814 8
An effective anti-human immunodeficiency virus-1 (HIV-1) microbicide should exert its action in the absence of causing aberrant activation of topical immunity that will increase the risk of HIV acquisition. In the present study, we demonstrated that the vaginal application of cellulose sulfate (CS) gel induced topical mucosal inflammatory responses; the addition of minocycline to CS gel could significantly attenuate the inflammation in a mice model. The combined gel of CS plus minocycline not on ...[more]