Ontology highlight
ABSTRACT:
SUBMITTER: Wu P
PROVIDER: S-EPMC3419191 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Wu Peng P Su Yi Y Guan Xianghong X Liu Xiaowen X Zhang Jiankang J Dong Xiaowu X Huang Wenhai W Hu Yongzhou Y
PloS one 20120814 8
<h4>Background</h4>Development of small-molecule inhibitors targeting phosphoinositide 3-kinase (PI3K) has been an appealing strategy for the treatment of various types of cancers.<h4>Methodology/principal finding</h4>Our approach was to perform structural modification and optimization based on previously identified morpholinoquinoxaline derivative WR1 and piperidinylquinoxaline derivative WR23 with a total of forty-five novel piperazinylquinoxaline derivatives synthesized. Most target compounds ...[more]