Ontology highlight
ABSTRACT:
SUBMITTER: Angle MR
PROVIDER: S-EPMC3419643 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Angle Matthew R MR Schaefer Andreas T AT
PloS one 20120815 8
Direct electrical recording of the neuronal transmembrane potential has been crucial to our understanding of the biophysical mechanisms subserving neuronal computation. Existing intracellular recording techniques, however, limit the accuracy and duration of such measurements by changing intracellular biochemistry and/or by damaging the plasma membrane. Here we demonstrate that nanoengineered electrodes can be used to record neuronal transmembrane potentials in brain tissue without causing these ...[more]