How genes influence life span: the biodemography of human survival.
Ontology highlight
ABSTRACT:
SUBMITTER: Yashin AI
PROVIDER: S-EPMC3419845 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Publications
How genes influence life span: the biodemography of human survival.
Yashin Anatoliy I AI Wu Deqing D Arbeev Konstantin G KG Stallard Eric E Land Kenneth C KC Ukraintseva Svetlana V SV
Rejuvenation research 20120518 4
<h4>Background</h4>In genome-wide association studies (GWAS) of human life span, none of the genetic variants has reached the level of genome-wide statistical significance. The roles of such variants in life span regulation remain unclear.<h4>Data and method</h4>A biodemographic analyses was done of genetic regulation of life span using data on low-significance longevity alleles selected in the earlier GWAS of the original Framingham cohort.<h4>Results</h4>Age-specific survival curves considered ...[more]
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