Ontology highlight
ABSTRACT:
SUBMITTER: Bossing T
PROVIDER: S-EPMC3420022 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Bossing Torsten T Barros Claudia S CS Fischer Bettina B Russell Steven S Shepherd David D
Developmental cell 20120726 2
Mechanisms of CNS repair have vital medical implications. We show that traumatic injury to the ventral midline of the embryonic Drosophila CNS activates cell divisions to replace lost cells. A pilot screen analyzing transcriptomes of single cells during repair pointed to downregulation of the microtubule-stabilizing GTPase mitochondrial Rho (Miro) and upregulation of the Jun transcription factor Jun-related antigen (Jra). Ectopic Miro expression can prevent midline divisions after damage, wherea ...[more]