Ontology highlight
ABSTRACT:
SUBMITTER: Qi W
PROVIDER: S-EPMC3420913 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Qi Wenjing W Huang Xu X Neumann-Haefelin Elke E Schulze Ekkehard E Baumeister Ralf R
PLoS genetics 20120816 8
In Caenorhabditis elegans (C. elegans), the promotion of longevity by the transcription factor DAF-16 requires reduced insulin/IGF receptor (IIR) signaling or the ablation of the germline, although the reason for the negative impact of germ cells is unknown. FOXO/DAF-16 activity inhibits germline proliferation in both daf-2 mutants and gld-1 tumors. In contrast to its function as a germline tumor suppressor, we now provide evidence that somatic DAF-16 in the presence of IIR signaling can also re ...[more]