Role of PARP inhibitors in cancer biology and therapy.
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ABSTRACT:
SUBMITTER: Davar D
PROVIDER: S-EPMC3421454 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
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Role of PARP inhibitors in cancer biology and therapy.
Davar D D Beumer J H JH Hamieh L L Tawbi H H
Current medicinal chemistry 20120101 23
Deeper understanding of DNA repair mechanisms and their potential value as therapeutic targets in oncology heralded the clinical development of poly(ADP-ribose) polymerase (PARP) inhibitors. Although initially developed to exploit synthetic lethality in models of cancer associated with defective DNA repair, our burgeoning knowledge of PARP biology has resulted in these agents being exploited both in cancer with select chemotherapeutic agents and in non-malignant diseases. In this review article, ...[more]
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