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Mutations in 23S rRNA confer resistance against azithromycin in Pseudomonas aeruginosa.

ABSTRACT: The emergence of antibiotic-resistant Pseudomonas aeruginosa is an important concern in the treatment of long-term airway infections in cystic fibrosis patients. In this study, we report the occurrence of azithromycin resistance among clinical P. aeruginosa DK2 isolates. We demonstrate that resistance is associated with specific mutations (A2058G, A2059G, and C2611T in Escherichia coli numbering) in domain V of 23S rRNA and that introduction of A2058G and C2611T into strain PAO1 results in azithromycin resistance.

SUBMITTER: Marvig RL

PROVIDER: S-EPMC3421623 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature

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Mutations in 23S rRNA confer resistance against azithromycin in Pseudomonas aeruginosa.

Marvig Rasmus Lykke RL Søndergaard Mette S R MS Damkiær Søren S Høiby Niels N Johansen Helle Krogh HK Molin Søren S Jelsbak Lars L

Antimicrobial agents and chemotherapy 20120529 8

The emergence of antibiotic-resistant Pseudomonas aeruginosa is an important concern in the treatment of long-term airway infections in cystic fibrosis patients. In this study, we report the occurrence of azithromycin resistance among clinical P. aeruginosa DK2 isolates. We demonstrate that resistance is associated with specific mutations (A2058G, A2059G, and C2611T in Escherichia coli numbering) in domain V of 23S rRNA and that introduction of A2058G and C2611T into strain PAO1 results in azith ...[more]

PMID: 22644032

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2020-12-21 | GSE151259 | GEO

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