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Catheter-related bacteremia caused by multidrug-resistant Leclercia adecarboxylata in a patient with breast cancer.

ABSTRACT: We report a multidrug-resistant strain of Leclercia adecarboxylata responsible for catheter-related bacteremia in a 47-year-old female with breast cancer. The isolated strain was resistant to several ?-lactams, aminoglycosides, and folate pathway inhibitors and harbored bla(TEM-1) and bla(CTX-M) group 1 and intl1 genes (dfrA12-orfF-aadA2) as genetic determinants for resistance. Based on a review of the L. adecarboxylata literature, there have been only 4 reports of antibiotic-resistant strains. To our knowledge, this is the first report of an L. adecarboxylata strain with simultaneous resistance to ?-lactams, aminoglycosides, and sulfonamides.

SUBMITTER: Shin GW

PROVIDER: S-EPMC3421816 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature

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Catheter-related bacteremia caused by multidrug-resistant Leclercia adecarboxylata in a patient with breast cancer.

Shin Gee-Wook GW You Myung-Jo MJ Lee Hye-Soo HS Lee Chang-Seop CS

Journal of clinical microbiology 20120703 9

We report a multidrug-resistant strain of Leclercia adecarboxylata responsible for catheter-related bacteremia in a 47-year-old female with breast cancer. The isolated strain was resistant to several β-lactams, aminoglycosides, and folate pathway inhibitors and harbored bla(TEM-1) and bla(CTX-M) group 1 and intl1 genes (dfrA12-orfF-aadA2) as genetic determinants for resistance. Based on a review of the L. adecarboxylata literature, there have been only 4 reports of antibiotic-resistant strains. ...[more]

PMID: 22760051

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