Molecular organization of small plasmids bearing blaTEM-1 and conferring resistance to ?-lactams in Haemophilus influenzae.
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ABSTRACT:
SUBMITTER: Sondergaard A
PROVIDER: S-EPMC3421876 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
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Molecular organization of small plasmids bearing blaTEM-1 and conferring resistance to β-lactams in Haemophilus influenzae.
Søndergaard Annette A San Millan Alvaro A Santos-Lopez Alfonso A Nielsen Signe M SM Gonzalez-Zorn Bruno B Nørskov-Lauritsen Niels N
Antimicrobial agents and chemotherapy 20120625 9
TEM-1 is the dominant β-lactamase of Haemophilus influenzae and can be located on small plasmids. Three distinct plasmids with sizes from 4,304 to 5,646 nucleotides (nt) were characterized: pA1606, pA1209, and pPN223. In addition to TEM-1 and a replication enzyme of the Rep 3 superfamily, pA1606 carries a Tn3 resolvase gene and pA1606 and pA1209 carry an open reading frame (ORF) similar to a plasmid recombination enzyme gene described in Gram-positive bacteria. The plasmids transformed strain Rd ...[more]
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