Ontology highlight
ABSTRACT:
SUBMITTER: Wyrsch P
PROVIDER: S-EPMC3422003 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Wyrsch Philippe P Blenn Christian C Bader Jessica J Althaus Felix R FR
Molecular and cellular biology 20120702 17
On the cellular level, oxidative stress may cause various responses, including autophagy and cell death. All of these outcomes involve disturbed Ca(2+) signaling. Here we show that the nuclear enzymes poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 control cytosolic Ca(2+) shifts from extracellular and intracellular sources associated with autophagy or cell death. The different Ca(2+) signals arise from the transient receptor potential melastatin 2 (TRPM2) channels located in the cellular and ly ...[more]