Dataset Information

Cutaneous squamous cell carcinoma metastatic to parotid - analysis of prognostic factors and treatment outcome.

ABSTRACT:

Background

Cutaneous squamous cell carcinoma (cSCC) comprises 20% of all skin cancer of the head and neck. A minority will metastasize to regional parotid lymph nodes. This study evaluates the St Vincent's Hospital, Sydney experience between 1996 and 2006.

Methods

A retrospective review was performed of patients who were evaluated in our multidisciplinary head and neck clinic with metastatic cSCC to parotid, and all treatment and pathologic details were reviewed. Statistical analysis, including univariate and multivariate analyses, were performed using Cox proportional hazards regression mode, overall and disease-specific survival were estimated by the Kaplan-Meier method.

Results

Sixty-seven patients were identified. Some 90?% were male, and with a mean age of 72.8?years. One died on the first postoperative day. The remaining 66 patients received radiotherapy. For these 66 patients, the two-year and five-year overall survival rate was 0.83 and 0.72, respectively. The two-year and five-year disease-free survival rate was 0.91 and 0.83 respectively. Overall survival was only significantly correlated to the extent of parotidectomy (superficial versus total; P?=?0.0256). Margin status was available in 59 patients. The only parameter that significantly correlated with disease-free survival was margin status (close/negative versus positive P?=?0.0348). Other parameters of immune suppression, perineural invasion, extra capsular extension, degree of tumour differentiation, number of positive nodes, extent of neck dissection and radiotherapy dosage delivered did not confer prognostic significance.

Conclusions

This study confirmed the association of adverse prognostic implication of positive margins on disease-free survival. Immune compromise was not a significant factor in this small group. Further studies are warranted in this population.

SUBMITTER: Goh RY

PROVIDER: S-EPMC3422189 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature

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Publications

Cutaneous squamous cell carcinoma metastatic to parotid - analysis of prognostic factors and treatment outcome.

Goh Robin Yeong Hong RY Bova Ron R Fogarty Gerald B GB

World journal of surgical oncology 20120625

<h4>Background</h4>Cutaneous squamous cell carcinoma (cSCC) comprises 20% of all skin cancer of the head and neck. A minority will metastasize to regional parotid lymph nodes. This study evaluates the St Vincent's Hospital, Sydney experience between 1996 and 2006.<h4>Methods</h4>A retrospective review was performed of patients who were evaluated in our multidisciplinary head and neck clinic with metastatic cSCC to parotid, and all treatment and pathologic details were reviewed. Statistical analy ...[more]

PMID: 22731750

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Project description:Pulmonary squamous cell carcinoma has not benefited from improvements in chemotherapy over the past decade, compared with non-squamous non-small-cell lung cancer. Nowadays, treatment strategies differ between squamous and non-squamous non-small-cell lung cancers. This study aimed to investigate the percentage of patients treated with first-, second-, or third-line chemotherapy and the characteristics of patients for whom chemotherapy has been beneficial.Data on patients with stage IIIB or IV squamous cell carcinoma diagnosed between June 2007 and March 2015, and on patients who had received first-, second-, or third-line chemotherapy between June 2007 and November 2015 at our hospital, were retrospectively extracted from our institutional medical charts. We also compared patients who were treated with chemotherapy (chemotherapy group) and patients who were not (non-chemotherapy group) using multivariate logistic regression and multivariate Cox hazard analyses, respectively.During the study period, 103, 63, and 32 patients received first-, second-, and third-line chemotherapy, respectively. Fifty-one patients did not receive chemotherapy. Factors predicting unlikely chemotherapy included age ?75 years, Eastern Cooperative Oncology Group (ECOG)-performance status (PS) ?2, Charlson comorbidity index ?2, hemoglobin <12.2 g/dL, red cell distribution width ?13.9%, and serum sodium <140 mEq/L. Factors predicting survival for each line of chemotherapy included the following: ECOG-PS ?2 for first-line; ECOG-PS ?2 and lymphocyte count for second-line; and ECOG-PS ?2, body mass index <18.5 kg/m2, and hemoglobin and lactate dehydrogenase levels for third-line.Approximately 66% of patients received first-line chemotherapy. Of those, 66% and 33% received second- and third-line chemotherapy, respectively. ECOG-PS was always an essential prognostic factor when considering introducing chemotherapy and proceeding with additional chemotherapy. Other markers, such as lymphocyte count, body mass index, anemia, and lactate dehydrogenase level, may be useful depending on the patient and line of chemotherapy.

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Dataset Information

Cutaneous squamous cell carcinoma metastatic to parotid - analysis of prognostic factors and treatment outcome.

Background

Methods

Results

Conclusions

Publications

Cutaneous squamous cell carcinoma metastatic to parotid - analysis of prognostic factors and treatment outcome.

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