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Probable congenital transmission of reticuloendotheliosis virus caused by vaccination with contaminated vaccines.

ABSTRACT: Contaminated vaccine is one unexpected and potential origin of virus infection. In order to investigate the most likely cause of disease in a broiler breeder company of Shandong Province, all 17 batches of live-virus vaccines used in the affected flocks and 478 tissue samples were tested by dot-blot hybridization, nested PCR, and IFA. The results suggested the outbreak of disease was most probably due to the vaccination of REV-contaminated MD-CVI988/Rispens vaccines and ND-LaSota+IB-H120 vaccines. Furthermore, the REV was probably transmitted to the commercial chickens through congenital transmission.

SUBMITTER: Wei K

PROVIDER: S-EPMC3422243 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Probable congenital transmission of reticuloendotheliosis virus caused by vaccination with contaminated vaccines.

Wei Kai K Sun Zhenhong Z Zhu Shufen S Guo Wenlong W Sheng Pengcheng P Wang Zunmin Z Zhao Changliang C Zhao Qingyou Q Zhu Ruiliang R

PloS one 20120817 8

Contaminated vaccine is one unexpected and potential origin of virus infection. In order to investigate the most likely cause of disease in a broiler breeder company of Shandong Province, all 17 batches of live-virus vaccines used in the affected flocks and 478 tissue samples were tested by dot-blot hybridization, nested PCR, and IFA. The results suggested the outbreak of disease was most probably due to the vaccination of REV-contaminated MD-CVI988/Rispens vaccines and ND-LaSota+IB-H120 vaccine ...[more]

PMID: 22912872

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