Ontology highlight
ABSTRACT:
SUBMITTER: Boren J
PROVIDER: S-EPMC3422477 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Cell death and differentiation 20120330 9
A characteristic of apoptosis is the rapid accumulation of cytoplasmic lipid droplets, which are composed largely of neutral lipids. The proton signals from these lipids have been used for the non-invasive detection of cell death using magnetic resonance spectroscopy. We show here that despite an apoptosis-induced decrease in the levels and activities of enzymes involved in lipogenesis, which occurs downstream of p53 activation and inhibition of the mTOR signaling pathway, the increase in lipid ...[more]