Ontology highlight
ABSTRACT:
SUBMITTER: Pathak R
PROVIDER: S-EPMC3422510 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Pathak Ritu R Delorme-Walker Violaine D VD Howell Michael C MC Anselmo Anthony N AN White Michael A MA Bokoch Gary M GM Dermardirossian Céline C
Developmental cell 20120801 2
The exocyst complex plays a critical role in targeting and tethering vesicles to specific sites of the plasma membrane. These events are crucial for polarized delivery of membrane components to the cell surface, which is critical for cell motility and division. Though Rho GTPases are involved in regulating actin dynamics and membrane trafficking, their role in exocyst-mediated vesicle targeting is not very clear. Herein, we present evidence that depletion of GEF-H1, a guanine nucleotide exchange ...[more]