Ontology highlight
ABSTRACT:
SUBMITTER: Varga Z
PROVIDER: S-EPMC3422703 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Molecular pharmacology 20120523 3
Blockade of Kv1.3 K(+) channels in T cells is a promising therapeutic approach for the treatment of autoimmune diseases such as multiple sclerosis and type 1 diabetes mellitus. Vm24 (α-KTx 23.1) is a novel 36-residue Kv1.3-specific peptide isolated from the venom of the scorpion Vaejovis mexicanus smithi. Vm24 inhibits Kv1.3 channels of human lymphocytes with high affinity (K(d) = 2.9 pM) and exhibits >1500-fold selectivity over other ion channels assayed. It inhibits the proliferation and Ca(2+ ...[more]