Transcriptional programs controlling perinatal lung maturation.
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ABSTRACT:
SUBMITTER: Xu Y
PROVIDER: S-EPMC3423373 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Transcriptional programs controlling perinatal lung maturation.
Xu Yan Y Wang Yanhua Y Besnard Valérie V Ikegami Machiko M Wert Susan E SE Heffner Caleb C Murray Stephen A SA Donahue Leah Rae LR Whitsett Jeffrey A JA
PloS one 20120820 8
The timing of lung maturation is controlled precisely by complex genetic and cellular programs. Lung immaturity following preterm birth frequently results in Respiratory Distress Syndrome (RDS) and Broncho-Pulmonary Dysplasia (BPD), which are leading causes of mortality and morbidity in preterm infants. Mechanisms synchronizing gestational length and lung maturation remain to be elucidated. In this study, we designed a genome-wide mRNA expression time-course study from E15.5 to Postnatal Day 0 ( ...[more]
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