Ontology highlight
ABSTRACT:
SUBMITTER: Schneider Rde O
PROVIDER: S-EPMC3423376 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Schneider Rafael de Oliveira Rde O Fogaça Natully de Souza Süffert Nde S Kmetzsch Lívia L Schrank Augusto A Vainstein Marilene Henning MH Staats Charley Christian CC
PloS one 20120820 8
Zinc homeostasis is essential for fungal growth, as this metal is a critical structural component of several proteins, including transcription factors. The fungal pathogen Cryptococcus gattii obtains zinc from the stringent zinc-limiting milieu of the host during the infection process. To characterize the zinc metabolism in C. gattii and its relationship to fungal virulence, the zinc finger protein Zap1 was functionally characterized. The C. gattii ZAP1 gene is an ortholog of the master regulato ...[more]