Genotyping of BRCA1, BRCA2, p53, CDKN2A, MLH1 and MSH2 genes in a male patient with secondary breast cancer.
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ABSTRACT:
SUBMITTER: Vodusek AL
PROVIDER: S-EPMC3423752 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Publications
Genotyping of BRCA1, BRCA2, p53, CDKN2A, MLH1 and MSH2 genes in a male patient with secondary breast cancer.
Vodusek Ana Lina AL Novakovic Srdjan S Stegel Vida V Jereb Berta B
Radiology and oncology 20110922 4
<h4>Background</h4>Some tumour suppressor genes (BRCA2) and mismatch repair genes (MSH2, MLH1) are correlated with an increased risk for male breast cancer.<h4>Case report</h4>Our patient developed secondary breast cancer after the treatment for Hodgkin's disease in childhood. DNA was isolated from the patients' blood and screened for mutations, polymorphisms and variants in BRCA1, BRCA2, p53, CDKN2A, MLH1 and MSH2 genes. We found no mutations but common polymorphisms, and three variants in mism ...[more]
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