Ontology highlight
ABSTRACT:
SUBMITTER: Jankowski W
PROVIDER: S-EPMC3423979 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Jankowski Wojciech W Saleh Tamjeed T Pai Ming-Tao MT Sriram Ganapathy G Birge Raymond B RB Kalodimos Charalampos G CG
Nature chemical biology 20120513 6
CrkL is a key signaling protein that mediates the leukemogenic activity of Bcr-Abl. CrkL is thought to adopt a structure that is similar to that of its CrkII homolog. The two proteins share high sequence identity and indistinguishable ligand binding preferences, yet they have distinct physiological roles. Here we show that the structures of CrkL and phosphorylated CrkL are markedly different than the corresponding structures of CrkII. As a result, the binding activities of the Src homology 2 and ...[more]