Ionizing radiation induces stemness in cancer cells.
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ABSTRACT:
SUBMITTER: Ghisolfi L
PROVIDER: S-EPMC3424153 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Ionizing radiation induces stemness in cancer cells.
Ghisolfi Laura L Keates Andrew C AC Hu Xingwang X Lee Dong-ki DK Li Chiang J CJ
PloS one 20120821 8
The cancer stem cell (CSC) model posits the presence of a small number of CSCs in the heterogeneous cancer cell population that are ultimately responsible for tumor initiation, as well as cancer recurrence and metastasis. CSCs have been isolated from a variety of human cancers and are able to generate a hierarchical and heterogeneous cancer cell population. CSCs are also resistant to conventional chemo- and radio-therapies. Here we report that ionizing radiation can induce stem cell-like propert ...[more]
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