Ontology highlight
ABSTRACT:
SUBMITTER: Frittoli E
PROVIDER: S-EPMC3424277 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Frittoli Emanuela E Matteoli Gianluca G Palamidessi Andrea A Mazzini Elisa E Maddaluno Luigi L Disanza Andrea A Yang Changsong C Svitkina Tatyana T Rescigno Maria M Scita Giorgio G
Immunity 20110811 3
Dendritic cells (DCs) flexibly adapt to different microenvironments by using diverse migration strategies that are ultimately dependent on the dynamics and structural organization of the actin cytoskeleton. Here, we have shown that DCs require the actin capping activity of the signaling adaptor Eps8 to polarize and to form elongated migratory protrusions. DCs from Eps8-deficient mice are impaired in directional and chemotactic migration in 3D in vitro and are delayed in reaching the draining lym ...[more]