Ontology highlight
ABSTRACT:
SUBMITTER: Flamar AL
PROVIDER: S-EPMC3424314 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Flamar Anne-Laure AL Zurawski Sandra S Scholz Felix F Gayet Ingrid I Ni Ling L Li Xiao-Hua XH Klechevsky Eynav E Quinn John J Oh Sangkon S Kaplan Daniel H DH Banchereau Jacques J Zurawski Gerard G
Journal of immunology (Baltimore, Md. : 1950) 20120803 5
Targeting of Ags directly to dendritic cells (DCs) through anti-DC receptor Ab fused to Ag proteins is a promising approach to vaccine development. However, not all Ags can be expressed as a rAb directly fused to a protein Ag. In this study, we show that noncovalent assembly of Ab-Ag complexes, mediated by interaction between dockerin and cohesin domains from cellulose-degrading bacteria, can greatly expand the range of Ags for this DC-targeting vaccine technology. rAbs with a dockerin domain fu ...[more]