Effect of tetrabenazine on computerized dynamic posturography in Huntington disease patients.

ABSTRACT:

Background

Impairment in computerized dynamic posturography scores has been documented in Huntington disease patients. Tetrabenazine is approved to treat chorea in Huntington disease, but its effect on posturography scores, and balance in general, is unknown.

Materials and methods

We designed a study to test computerized dynamic posturography performance while taking tetrabenazine and after stopping tetrabenazine for at least three days.

Results

10 Huntington disease patients were studied both ON and OFF tetrabenazine. The composite score was statistically different between ON and OFF conditions and both conditions were significantly worse than reference scores. There was no significant difference between ON and OFF trials in the number of falls. A significant improve

SUBMITTER: Fekete R 

PROVIDER: S-EPMC3424328 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature