Ontology highlight
ABSTRACT:
SUBMITTER: Wald N
PROVIDER: S-EPMC3424539 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Wald Naama N Alroy Maya M Botzman Maya M Margalit Hanah H
Nucleic acids research 20120511 15
Synonymous codons are unevenly distributed among genes, a phenomenon termed codon usage bias. Understanding the patterns of codon bias and the forces shaping them is a major step towards elucidating the adaptive advantage codon choice can confer at the level of individual genes and organisms. Here, we perform a large-scale analysis to assess codon usage bias pattern of pyrimidine-ending codons in highly expressed genes in prokaryotes. We find a bias pattern linked to the degeneracy of the encode ...[more]