Ontology highlight
ABSTRACT:
SUBMITTER: Garg A
PROVIDER: S-EPMC3424557 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Garg Abhishek A Lohmueller Jason J JJ Silver Pamela A PA Armel Thomas Z TZ
Nucleic acids research 20120511 15
The ability to engineer biological circuits that process and respond to complex cellular signals has the potential to impact many areas of biology and medicine. Transcriptional activator-like effectors (TALEs) have emerged as an attractive component for engineering these circuits, as TALEs can be designed de novo to target a given DNA sequence. Currently, however, the use of TALEs is limited by degeneracy in the site-specific manner by which they recognize DNA. Here, we propose an algorithm to c ...[more]