Ontology highlight
ABSTRACT:
SUBMITTER: Yeung F
PROVIDER: S-EPMC3424578 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Yeung Fan F Chung Eunhee E Guess Martin G MG Bell Matthew L ML Leinwand Leslie A LA
Nucleic acids research 20120525 15
The sarcomeric myosin gene, Myh7b, encodes an intronic microRNA, miR-499, which regulates cardiac and skeletal muscle biology, yet little is known about its transcriptional regulation. To identify the transcription factors involved in regulating Myh7b/miR-499 gene expression, we have mapped the transcriptional start sites and identified an upstream 6.2 kb region of the mouse Myh7b gene whose activity mimics the expression pattern of the endogenous Myh7b gene both in vitro and in vivo. Through pr ...[more]