Ontology highlight
ABSTRACT:
SUBMITTER: Lindor NM
PROVIDER: S-EPMC3425611 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Lindor Noralane M NM Petersen Gloria M GM Spurdle Amanda B AB Thompson Bryony B Goldgar David E DE Thibodeau Stephen N SN
Pancreas 20111001 7
<h4>Objective</h4>The objective of this study was to describe a novel MSH2 missense alteration cosegregating with pancreatic cancer.<h4>Methods</h4>The method used was an observational study of a kindred in which a novel MSH2 missense alteration was identified.<h4>Results</h4>We report a family in which a MSH2 P349L missense alteration is cosegregating with pancreatic cancers among 3 nonsmoking first-degree relatives. Lynch syndrome-related tumors from individuals carrying this alteration consis ...[more]