Ontology highlight
ABSTRACT:
SUBMITTER: Tobinai K
PROVIDER: S-EPMC3425744 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Tobinai Kensei K Takahashi Takeshi T Akinaga Shiro S
Current hematologic malignancy reports 20120901 3
Peripheral T-cell lymphoma (PTCL) is a group of lymphoid malignancy that remains difficult to treat, as most PTCL becomes refractory or relapses, and thus there is an unmet medical need for novel treatment modalities. CC chemokine receptor 4 (CCR4) is expressed in various types of PTCL including adult T-cell leukemia-lymphoma (ATL), which has the worst prognosis among them. A phase II study of a defucosylated, humanized anti-CCR4 monoclonal antibody, mogamulizumab (KW-0761), yielded an overall r ...[more]