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Genetic association of GABA-A receptor alpha-2 and mu opioid receptor with cocaine cue-reactivity: evidence for inhibitory synaptic neurotransmission involvement in cocaine dependence.

ABSTRACT: This pilot feasibility study examined the role of genetics in laboratory-induced cocaine craving.Thirty-four African American, cocaine-depend- ent male subjects underwent a baseline assessment, cue-exposure session, and genetic analysis. Subjects were classified as either cue-reactive or nonreactive.Among single nucleotide polymorphism markers in 13 candidate genes examined for association with cocaine cue-reactivity, two were statistically significant: GABRA2 (coding for GABA-A receptor alpha-2 subunit; rs11503014, nominal p= .001) and OPRM1 (coding for mu opioid receptor; rs2236256, nominal p= .03).These pilot results suggest that cocaine craving shows variability among cocaine-dependent subjects, and that GABRA2 and OPRM1 polymorphisms have differential influences on cocaine cue-reactivity, warranting studies in future research.

SUBMITTER: Smelson D 

PROVIDER: S-EPMC3425941 | biostudies-literature | 2012 Sep-Oct

REPOSITORIES: biostudies-literature

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Genetic association of GABA-A receptor alpha-2 and mu opioid receptor with cocaine cue-reactivity: evidence for inhibitory synaptic neurotransmission involvement in cocaine dependence.

Smelson David D   Yu Lei L   Buyske Steven S   Gonzalez Gerardo G   Tischfield Jay J   Deutsch Curtis K CK   Ziedonis Douglas D  

The American journal on addictions 20120901 5

<h4>Background</h4>This pilot feasibility study examined the role of genetics in laboratory-induced cocaine craving.<h4>Methods</h4>Thirty-four African American, cocaine-depend- ent male subjects underwent a baseline assessment, cue-exposure session, and genetic analysis. Subjects were classified as either cue-reactive or nonreactive.<h4>Results</h4>Among single nucleotide polymorphism markers in 13 candidate genes examined for association with cocaine cue-reactivity, two were statistically sign  ...[more]

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